| Registro completo |
| Provedor de dados: |
Arq. Bras. Med. Vet. Zootec.
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| País: |
Brazil
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| Título: |
Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
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| Autores: |
Souza,A.H.
Valadão,C.A.A.
Selegatto,M.A.
Almeida,R.M.
Macari,M.
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| Data: |
2008-06-01
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| Ano: |
2008
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| Palavras-chave: |
LPS
Fever
DMSO
Rabbits
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| Resumo: |
The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016
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| Editor: |
Universidade Federal de Minas Gerais, Escola de Veterinária
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| Relação: |
10.1590/S0102-09352008000300016
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| Formato: |
text/html
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| Fonte: |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.60 n.3 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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